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Antimicrobial activity of a compound isolated from an oil-macerated garlic extract
Authors:H Yoshida  N Iwata  H Katsuzaki  R Naganawa  K Ishikawa  H Fukuda  T Fujino  A Suzuki
Affiliation:Biodevelopment Division, Central Institute, Nagoya Seiraku Co., Ltd., Aichi, Japan.
Abstract:A compound showing antimicrobial activity was isolated from an oil-macerated garlic extract by silica gel column chromatography and preparative TLC. On basis of the results of NMR and MS analyses, it was identified as Z-4,5,9-trithiadeca-1,6-diene-9-oxide (Z-10-devinylajoene; Z-10-DA). Z-10-DA exhibited a broad spectrum of antimicrobial activity against such microorganisms as gram-positive and gram-negative bacteria and yeasts. The antimicrobial activity of Z-10-DA was comparable to that of Z-ajoene, but was superior to that of E-ajoene. Z-10-DA and Z-ajoene are different in respect of substitution of the allyl group by the methyl group flanking a sulfinyl group. This result suggests that substitution by the methyl group would also be effective for the inhibition of microbial growth.
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