| 苯卟啉衍生物单环酸A（BPD—MA）在兔血浆中的代谢特性 |
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| 引用本文： | 孙业勤 顾瑛 等. 苯卟啉衍生物单环酸A（BPD—MA）在兔血浆中的代谢特性[J]. 激光杂志, 2001, 22(4): 60-61 |
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| 作者姓名： | 孙业勤 顾瑛 等 |
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| 作者单位： | [1]第一军医大学南方医院心内科，广州510515 [2]中国人民解放军总医院激光科，北京100853 |
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| 摘 要： | 目的：在体条件下分析兔血浆中的BPD-MA的吸收特性及排出情况，为BPD-MA用于PDT治疗血管性疾病的可行性和时机选择提供依据，方法：动物给药后，在不同时间取血，采取荧光分光光度法测定BPD-MA含量。结果：兔血浆中BPD-MA含量在给药后5min最高，5-20min下降最快，20min后下降幅度减慢，120min趋于稳定，当给药量为5mg/kg时，血药浓度变化最明显，结论：血浆药物浓度与给药浓度有关，随时间的变化呈典型的峰值-快速下降期-平台期。
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| 关 键 词： | 苯卟啉衍生物 单环酸 兔血浆 化谢特性 |
distribution of benzoporphyrin derivative monoacid ring A(BPD-MA) in rabbit plasma |
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| Sun Yeqin Liu Aiqin Liu Fanguang Meng Surong Gu Ying Tang Jianmin. distribution of benzoporphyrin derivative monoacid ring A(BPD-MA) in rabbit plasma[J]. Laser Journal, 2001, 22(4): 60-61 |
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| Authors: | Sun Yeqin Liu Aiqin Liu Fanguang Meng Surong Gu Ying Tang Jianmin |
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| Affiliation: | Sun Yeqin 1 Liu Aiqin 3 Liu Fanguang 2 Meng Surong 1 Gu Ying 2 Tang Jianmin 3 |
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| Abstract: | Objective:To investigate the absorption characteristic of BPD-MA in rabbit plasma.Method:Rabbit plasma tissue was isolated after drug administration and fluorospectrophotometer was used to measure the content of BPD-MA.Results:Content of BPD-MA in plasma was highest at 5min,reached plateau at 20min and got stable phase at 120min after injection.The change of blood concentration of BPD-MA was most distinctive when its dosage was 5mg/kg.Conclusion:The concentration of BPD-MA in plasma is dosage-dependent,and its change is the typical type as:peak-rapid descending-plateau. |
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| Keywords: | plasma distribution BPD-MA |
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