Abstract: | The method described allows the production of 1–2 μm sections of large tissue blocks. Sections can be obtained from conventional routine histological microtomes. The hydroxyethyl methacrylate is compatible with a wide range of fixatives and a variety of standard histological staining techniques may be applied. Small biopsies, e.g. renal, liver, jejunal etc., can be processed cut and stained within 24 h of receipt. Blocks and stained sections show no apparent deterioration over the 4 years in which the technique has been employed in this laboratory. |