Hydroxyapatite/poly(L-lactic acid)-chitosan Porous Scaffolds Prepared by Phase Separation Method |
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Authors: | Guojie Xu Zhihang He Qiongyu Huang |
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Affiliation: | College of Chemistry and Chemical Engineering, Fujian Normal University, Fuzhou, China |
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Abstract: | Hydroxyapatite/poly(L-lactic acid)–chitosan and poly(L-lactic acid)/chitosan porous scaffolds were prepared by phase separation technique using heated acetic acid–water as a common solvent of poly(L-lactic acid) and chitosan. The results show that the distribution of hydroxyapatite in the scaffolds is good. The porosity of the hydroxyapatite/poly(L-lactic acid)–chitosan scaffolds is nearly 85%. The hydroxyapatite particles in the scaffolds are beneficial for improving the compression property of the scaffolds. The in vitro bioactivity test shows that there is a low crystallinity of carbonate hydroxyapatite coating formed on the surface of the scaffold after immersing in simulated body fluid for 14 days, indicating that the hydroxyapatite/poly(L-lactic acid)–chitosan scaffolds have a good bioactivity. |
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Keywords: | Bioactivity Chitosan Hydroxyapatite Phase separation L-lactic acid)" target="_blank">Poly(L-lactic acid) |
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