| 连翘酯苷A中压快速制备工艺的优化 |
| |
| 引用本文： | 何文珑,;贾金萍,;张立伟.连翘酯苷A中压快速制备工艺的优化[J].食品工程,2014(2):20-22. |
| |
| 作者姓名： | 何文珑 ;贾金萍 ;张立伟 |
| |
| 作者单位： | [1]山西大学分子科学研究所,山西太原030006; [2]山西大学中医药现代研究中心,山西太原030006; [3]山西大学化学化工学院,山西太原030006 |
| |
| 基金项目： | 科技部科技支撑计划（2011BA107806）;山西省科学技术发展计划（20110313001-1）. |
| |
| 摘 要： | 为获得一种易操作、高效、高纯度的连翘酯苷A制备工艺,以聚酰胺和MDS-5为分离材料,采用单因素多水平试验的方法考察上样量、上样浓度、洗脱流速等因素对连翘酯苷A得率和纯度的影响,优化两步柱分离纯化工艺条件。试验结果表明,以聚酰胺为分离材料可获得连翘酯苷A含量为50%的产物,产物以MDS为分离材料进一步分离可获得连翘酯苷A含量为90%的产物。本方法具有分离效率高、溶剂毒性小等优点,是一种获得高含量连翘酯苷A的简便、高效、经济的方法。
|
| 关 键 词： | 聚酰胺 中压制备液相色谱 制备工艺 |
Optimization of polyamide medium voltage preparation technology for forsythiaside A |
| |
| Affiliation: | HE Wen-long, JIA Jin-ping, ZHANG Li-wei 1 (institute for molecular science, Shanxi university, Shanxi Taiyuan 030006 China) 2( Modem research center of traditional Chinese medicine, Shanxi university, Shanxi Taiyuan 030006 China) 3(College of chemistry and chemical engineering, Shanxi university, Shanxi Taiyuan 030006 China) |
| |
| Abstract: | To research a preparation technology of forsythiaside A with easy, efficient and pure. To investigate the quantity of samples, the concentration of samples and the current speed of the univariate multi-level experiment with the purity and the yield of forsythiaside A, by using polyamide and MDS-5 as the separating material. The twice column separation method will be optimized. We can obtain the 50% of forsythiaside A by using polyamide, and they will fur-ther purify into the 90% of forsythiaside A by using MDS-5. This method is efficient, low toxicity, simple and econom-ical. |
| |
| Keywords: | 连翘酯苷 A forsythiaside A polyamide preparative medium pressure liquid chromatography preparation technology |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
