银杏果精多糖的降血脂作用

采用水提醇沉法提取,Sevag法除蛋白,大孔树脂法脱色精制多糖,并对高脂模型小鼠进行实验,研究银杏果精多糖对高脂模型小鼠体重、脏器指数、血清的总胆固醇(TC)、甘油三脂(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)和动脉粥样硬化指数(AI)的影响。结果表明:银杏果精多糖高剂量组能显著降低小鼠体重和肝脏指数,提高小鼠肾脏指数,也能使小鼠血清中TC、TG和LDL-C的含量显著降低、HDL-C的含量显著升高、AI指数显著下降;银杏果精多糖中剂量组能使小鼠血清中TG和LDL-C的含量显著降低、AI指数显著下降;银杏果精多糖低剂量组可使小鼠血清中TG的含量显著降低、AI指数显著下降。说明银杏果精多糖具有降血脂作用,对冠心病和动脉粥样硬化有一定的预防作用。

Study on the effect of ginkgo polysaccharides on hypolipidemic

Refined polysaccharides were obtained by water extraction,then alcohol precipitation,Sevag protein removal method and macroreticular resin decolorization.Then the refined polysaccharides was tested on mice.The effects on the weight of mice,visceral index,total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C) and atherosclerosis index(AI) of mice serum were studied.Results indicated that in the high-dose polysaccharide group,the weight of mice and visceral index were dropped dramatically on group,do did TC,TG and LDL-C of mice serum and AI;HDL-C was significant increased.In the medial-dose group,TG and LDL-C of mice serum and AI were dropped dramatically.In low-dose group,TG of mice serum and AI were able to drop dramatically.These results demonstrated that ginkgo nut fine polysaccharide could reduce plasma lipids and had a certain effect in preventing coronary heart disease and atherosclerosis.