紫菜多肽降血脂及抗氧化作用的研究

为探讨紫菜多肽的血脂调节和抗氧化作用,通过动物实验,建立了高血脂大鼠模型,比较分析了紫菜多肽对高血脂大鼠体质量、肝脏系数、血脂指标及过氧化指标的影响情况。结果显示,紫菜多肽各剂量组大鼠的体质量增加幅度较高脂模型组有显著下降;血清TC、TG和LDL-C含量降低,HDL-C含量升高,综合表现为AI降低;血清中GSH-Px和SOD活性升高,MDA含量降低;肝脏组织中GSH-Px活性升高,MDA含量降低,但肝脏系数和SOD活性变化不大。研究表明,紫菜多肽能有效控制高血脂模型大鼠体质量的增加,改善血脂水平,提高抗氧化酶活力,抑制脂质过氧化反应,降低患动脉硬化疾病的风险。 

Study on the hypolipidemic effects and antioxidative activity of porphyra peptide

To study the hypolipidemic effects and antioxidation of porphyra peptide, hyperlipidemic rats were induced to analyze the hypolipidemic effects and antioxidant of porphyra peptide on weights, liver coefficient, lipid index and antioxidative index in hyperlipidemic rate. Results showed that a significant reduction on weight gain in the groups with different doses of porphyra peptide. The serum TC, TG and LDL-C were decreased while HDL-C was elevated, which showed a lower AI. The activity of serum GSH-Px and SOD were higher, while MDA was lower, but liver coefficient and SOD activity remained. In conclusion, porphyra peptide had obvious effects on controlling weight gain, improved lipid index, increased antioxidase activity, inhibited of lipid peroxidation and reduced the risk of arteriosclerosis.