精细化工中间体2-氯烟酸的合成

2-氯烟酸是一种重要的医药和农药中间体,用途广泛.采用3步合成法,即以3-氰基吡啶和双氧水为起始原料,经氧化生成3-氰基吡啶N氧化物,再氯化生成2-氯-3-氰基吡啶,再水解生成2-氯烟酸,产物纯度99.5%,总收率70.0%以上,确定了反应物配比、反应温度、反应时间等工艺参数.

Synthesis of Intermediate 2-Chloronicotinic Acid

2-Chloronicotinic acid is one kind of the important medical and agrochemical intermediate,3-cyanopyridine and aqueous hydrogen peroxide were used as main materials to prepare 3-Cyanopyridine N-oxide by oxidation,followed by chloridization to prepare 2-Choloro-3-cyanopyridine,and then by hydrolyation to prepare 2- Chloronicotinic acid. Products with mass content of 99.5% and the total yield was more than 70%. Studys on the different technic parameters such as the substrate proportion,reaction temperature and reaction time.