pH sensitive supramolecular vesicles from cyclodextrin graft copolymer and benzimidazole ended block copolymer as dual drug carriers |
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| Authors: | Xuejun Cui Nairong Wang Hongsheng Wang Qian Tao |
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| Affiliation: | 1. Hospital of Ludong University, Yantai, China;2. College Chemistry and Materials Science, Ludong University, Yantai, China |
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| Abstract: | Supramolecular assemblies from chitosan-graft-β-cyclodextrin (CS-g-CD) and benzimidazole ended poly(ethylene glycol)-block-poly(ε-caprolactone) (PEG-b-PCL-BM) were formed based on the inclusion complexation between β-cyclodextrin and benzimidazole. The supra-amphiphiles self-assembled into complex vesicles with PCL/β-CD as the hydrophobic membrane, hydrophilic PEG and CS as the corona. The hydrophobic membrane and aqueous lumen of vesicles exhibited efficient entrapment both for hydrophobic curcumin (CUR) and hydrophilic doxorubicin (DOX). The drug loading of vesicles was more than 20.2% and 38.4% for CUR and DOX, respectively. Decreasing pH to acidic condition or increasing temperature, more controllable and rapid release of two drugs was observed. Cytotoxicity assays revealed that dual drug-loaded vesicles retained high cell proliferation inhibition efficiency than free drugs.GRAPHICAL ABSTRACT | |
| Keywords: | Benzimidazole cyclodextrin dual-drug carriers inclusion complexation supramolecular vesicles |
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