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Effect of pseudomonas lipase enzyme on the degradation of polycaprolactone/polycaprolactone-polyglycolide fiber blended nanocomposites |
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| Authors: | Shayla S. Spearman Fahmida Irin Srikanthan Ramesh Micah J. Green Ola L. A. Harrysson |
| Affiliation: | 1. Department of Industrial Engineering, Texas Tech University, Lubbock, TX, USA;2. Department of Systems and Industrial Engineering, Kennesaw State University, Marietta, GA, USA;3. Artie McFerrin Department of Chemical Engineering, Texas A&4. M University, College Station, TX, USA;5. Department of Industrial and Manufacturing Systems Engineering, Iowa State University, Ames, IA, USA;6. Edward P. Fitts Department of Industrial and Systems Engineering, North Carolina State University, Raleigh, NC, USA |
| Abstract: | This study describes the interaction resulting from adding pseudomonas lipase (PS) enzyme to polycaprolactone-based composites designed for orthopedic applications. The biopolymer composite evaluated in this study consists of electrospun polycaprolactone (PCL)/polyglycolide (PGA) blended fibers impregnated with double stranded deoxyribonucleic acid wrapped single-walled carbon nanotubes encapsulated by a PCL matrix. PS enzyme was used to catalyze the degradation of PCL-based biocomposites. PCL present in the biocomposites showed considerable degradation in 4 weeks in the presence of the enzyme, exhibiting a contrast to hydrolytic degradation which lasts several years. PGA-consisting fibers degraded completely within one week of exposure to the enzyme. |
| Keywords: | Biodegradable composites biopolymers electrospinning enzymatic degradation orthopedic implants |