Curcumin loaded fish scale collagen-HPMC nanogel for wound healing application: Ex-vivo and In-vivo evaluation |
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| Authors: | Dr Inayat B Pathan Mr Santosh J Munde Dr Santosh Shelke Professor Wahid Ambekar Dr C Mallikarjuna Setty |
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| Affiliation: | 1. Department of Pharmaceutics, Government College of Pharmacy, Aurangabad, Maharashtra, India;2. Department of Pharmaceutics, Yash Institute of Pharmacy, Aurangabad, Maharashtra, India;3. Department of Pharmaceutics, Dr. VVPF’s College of Pharmacy, Ahmednagar, Maharashtra, India;4. Department of Pharmaceutics, The Oxford College of Pharmacy, Pharmaceutics, Hongasandra, Bangalore, India |
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| Abstract: | The objective of the present investigation was to formulate curcumin loaded fish scale collagen (FSC)-hydroxypropyl methyl cellulose (HPMC K100) nanogel (CNG) for wound healing application. The curcumin nanoemulsion was prepared, characterized and loaded in FSC-HPMC nanogel. The nanogel was evaluated for ex-vivo permeation, in-vivo, skin irritation, and stability study. Ex-vivo permeation study demonstrated that CNG prolonged release and exhibited higher percent contraction value of wound compared to other formulations. In skin irritation study, formulation produced the score of less than 2 compared to control. It concluded that curcumin loaded FSC-HPMC nanogel could be prepared for wound healing applications. |
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| Keywords: | Curcumin fish scale collagen nanoemulsion wound healing activity |
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