NMR study of the phosphonomethylation reaction on chitosan |
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Authors: | Fanny Lebouc Pierre-Jean Madec |
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Affiliation: | Laboratoire de Chimie Moléculaire et Thioorganique, UMR CNRS 6507, ENSICAEN, Université de Caen, 6 Boulevard du Maréchal Juin, 14050 Caen Cedex, France |
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Abstract: | N-Phosphonomethylation of chitosan reaction was studied and optimized using different reaction conditions. NMR spectroscopy was an important tool in this work to study this reaction and the α-aminomethylphosphonic acid function introduced onto chitosan was unequivocally characterized by 31P and 13C NMR analyses. But surprisingly, whatever the reaction conditions used, N-phosphonomethylation reaction of chitosan cannot be dissociated from a side reaction: the N-methylation reaction of chitosan. A mechanism was proposed to explain the formation of this side product. |
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Keywords: | Chitosan Phosphonomethylation NMR |
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