Coupling of Phosphates on Alumina Surfaces for Bioactivation |
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| Authors: | Nadine Kaltenborn,Michael Sax,Frank A. Mü ller,Lenka Mü ller,Henning Dieker,Arno Kaiser,Rainer Telle, Horst Fischer |
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| Affiliation: | Department of Ceramics and Refractory Materials, RWTH Aachen University, 52064 Aachen, Germany; Hermsdorfer Institut für Technische Keramik e. V., 07629 Hermsdorf, Germany; IBS, 49457 Drebber, Germany; Department of Materials Science (III) Biomaterials, University of Erlangen-Nuernberg, 91052 Erlangen, Germany; Department of Physics, I. Physikalisches Institut, RWTH Aachen University, 52064 Aachen, Germany |
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| Abstract: | This paper reports on a new surface treatment, coupling phosphates on alumina surfaces for bioactivation. Alumina samples were treated in monoaluminumphosphate solution at 1400°C. Strongly coupled aluminum phosphates due to the treatment were proved by X-ray diffraction and infrared spectroscopy. Contact angle measurements proved the hydrophilic nature of the treated surface. In vitro tests in simulated body fluid indicated a bioactive behavior by means of apatite-forming ability. Such functionalized alumina ceramics imply the potential for a new class of bioactive high-strength ceramic implant materials, due to a pronounced affinity of bioactive phosphate groups to particular amino acid sequences of proteins. |
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