Clinical Implications of Exosomes: Targeted Drug Delivery for Cancer Treatment |
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| Authors: | Andrew E Massey Shabnam Malik Mohammad Sikander Kyle A Doxtater Manish K Tripathi Sheema Khan Murali M Yallapu Meena Jaggi Subhash C Chauhan Bilal B Hafeez |
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| Affiliation: | 1.National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, Bethesda, MD 20892, USA;2.Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA; (S.M.); (M.S.); (K.A.D.); (M.K.T.); (S.K.); (M.M.Y.); (M.J.) |
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| Abstract: | Exosomes are nanoscale vesicles generated by cells for intercellular communication. Due to their composition, significant research has been conducted to transform these particles into specific delivery systems for various disease states. In this review, we discuss the common isolation and loading methods of exosomes, some of the major roles of exosomes in the tumor microenvironment, as well as discuss recent applications of exosomes as drug delivery vessels and the resulting clinical implications. |
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| Keywords: | exosome tumor microenvironment miRNAs lncRNAs |
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