2-氨基-6-羟基-3,5-二硝基吡啶的合成探索

2-氨基-6-羟基-3,5-二硝基吡啶(AHDNP)是合成聚对苯亚乙基吡啶并咪 二唑(PPIO)重要前体.本文以2,6-二氯吡啶为原料经单硝化、单氨解、再硝化先合成中间体2-氨基-6-氯-3,5-二硝基吡啶(ACDNP),纯度为95.60%,总收率41.00%以上;最后在K₂CO₃的碱性水溶液中70℃条件下单水解,成功合成出AHDNP,提纯后总收率为82.07%,纯度为98.13%.AHDNP的结构经过FT-IR、MS、¹³C NMR 准确定性和表征.合成过程操作方便、产品质量优异、经济性良好及易于产业化,为进一步研发合成新型高性能材料PPIO及其新单体提供技术基础及中间体来源.

Synthesis of 2-amino-6-hydroxy-3,5-dinitropyridine

As a key intermediate for poly (p-phenylene-2-pyridinoimidazol-6-oxazole),2-amino-6- chloro-3,5-dinitropyridine(ACDNP) with 95.60% and the total yield of 41% was obtained from 2,6-dichloropyridine by nitration,ammonolysis and nitration. 2-Amino-6-hydroxy- 3,5-dinitropyridine (AHDNP) was prepared from ACDNP in potassium carbonate solution at 70℃. The purity of AHDNP was 82.07% and the total yield of AHDNP is 98.13% after re-crystallization. AHDNP was identified by FT-IR,MS and ¹³C NMR. This process for AHDNP synthesis has advantages of simple operation procedure,excellent product quality,good economy and easy industrialization etc.,which provides convenience for further development of PPIO and other high-performance materials.