| 甘油二酯对高胆固醇血症大鼠血脂及体成分的影响 |
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| 引用本文： | 罗佳宪邹琼朱惠莲杨博王永华. 甘油二酯对高胆固醇血症大鼠血脂及体成分的影响[J]. 中国油脂, 2020, 45(3): 85-89 |
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| 作者姓名： | 罗佳宪邹琼朱惠莲杨博王永华 |
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| 作者单位： | 1.华南理工大学 生物科学与工程学院，广州 510006； 2.广东粤膳特医营养科技有限公司，广东 佛山 528000； 3.中山大学 公共卫生学院，广州 510080； 4.华南理工大学 食品科学与工程学院，广州 510641 |
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| 基金项目： | 国家自然科学基金（31601398）；佛山市南海区“蓝海人才计划”创新创业团队（201811070001） |
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| 摘 要： | 采用高脂饲料建立大鼠高胆固醇血症模型,同时设正常组作对照,将高胆固醇血症大鼠按血清总胆固醇水平随机分成2组,即TAG组、甘油二酯(DAG)组,喂养30 d,研究各组大鼠血清中总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)含量变化及体成分变化、肝组织病理学特性等,以评价DAG对高胆固醇血症的作用。结果表明:DAG对高胆固醇血症大鼠的血脂具有一定的优化效果,具体表现为可以升高高胆固醇血症大鼠血清HDL-C,可明显减轻高胆固醇血症肝细胞脂肪变性。
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| 关 键 词： | 甘油二酯（DAG）；高胆固醇血症；血脂；体成分；脂肪肝 |
Effects of diacylglycerol on blood lipid metabolism and body composition of rats with hypercholesterolemia |
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| LUO JiaxianZOU QiongZHU HuilianYANG BoWANG Yonghua. Effects of diacylglycerol on blood lipid metabolism and body composition of rats with hypercholesterolemia[J]. China Oils and Fats, 2020, 45(3): 85-89 |
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| Authors: | LUO JiaxianZOU QiongZHU HuilianYANG BoWANG Yonghua |
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| Abstract: | The rat models of hypercholesterolemia were established with high fat diet and normal rats were adopted as the control group. After the establishment of the model, rats were randomly divided into 2 groups of TAG and diacylglycerol(DAG) based on the total serum cholesterol. The experiment lasted thirty days, and then the changes in total cholesterol(TC), triglyceride(TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and body composition of the rats, as well as the histopathology in rats liver tissue were determined so as to evaluate the effect of DAG on hypercholesterolemia rats. The results showed that DAG had a certain optimization effect on the blood lipid of hypercholesterolemia rats, which showed that DAG could improve serum HDL-C in hyperlipidemia rats, and significantly decrease hepatocellular steatosis. |
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