| 基于磁感应QCM在早期肺癌检测上的研究 |
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| 引用本文： | 张艳丽,崔大祥,惠春,徐爱兰,黄斌峰.基于磁感应QCM在早期肺癌检测上的研究[J].传感器与微系统,2009,28(9):50-52. |
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| 作者姓名： | 张艳丽 崔大祥 惠春 徐爱兰 黄斌峰 |
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| 作者单位： | 张艳丽(上海交通大学,生命科学技术研究院,上海,200240;上海交通大学,微纳科学技术研究院,上海,200240);崔大祥,徐爱兰(上海交通大学,微纳科学技术研究院,上海,200240);惠春,黄斌峰(上海交通大学,生命科学技术研究院,上海,200240) |
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| 基金项目： | 上海市纳米技术专项基金资助项目 |
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| 摘 要： | 利用压电石英晶体的振动频率对其电极表面负荷敏感的特点和现场可编程（逻辑）门阵列（FP-GA）与单片机的控制功能，同时，利用纳米免疫磁微珠具有增大负载响应和磁分离的能力，结合特异性生物化学反应，设计了一种用于早期肺癌诊断的纳米生物电子微系统。通过该系统对蒸馏水和CPA—Y2肺癌细胞溶液的测量结果表明：该系统具有较好的线性变化规律，能准确反映被测生物物质的质量或含量，对实现肺癌的早期诊断和筛查具有重要的参考价值。
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| 关 键 词： | 磁感应 石英晶体微天平 谐振频率 现场可编程(逻辑)门阵列 |
Research of early lung cancer detection based on magnetic QCM |
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| Affiliation: | ZHANG Yan-li, CUI Da-xiang , HUI Chun, XU Ai-lan , HUANG Bin-feng ( 1. School of Life Sciences ＆ Bioteehnology, Shanghai Jiaotong University, Shanghai 200240, China; 2. Research Institute of Miero/Nano Sciences ＆ Technology, Shanghai Jiaotong University, Shanghai 200240, China) |
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| Abstract: | A nano-electronic detection system which is based on the principle that the vibration frequency of piezoelectric quartz crystal is sensitive to the load of its electrodes surface, also combined with the control ability of FPGA, single-chip and that nano-magnetic beads have the ability of improving the load response and biochemical reactions is designed,the system hopefully will be used for the detection of early lung cancer. According to the system testing result of distilled water and lung cancer cell CPA-Y2, which show that the system has a good linearity and can accurately reflect the quality or content of biological material. This system has important value of reference for early diagnosis of lung cancer. |
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| Keywords: | magnetic induction QCM resonant frequency FPGA |
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