| 2-氯烟酸合成工艺研究 |
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| 引用本文： | 聂文娜.2-氯烟酸合成工艺研究[J].河北化工,2006,29(10):14-15,18. |
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| 作者姓名： | 聂文娜 |
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| 作者单位： | 河北亚诺化工有限公司,河北,石家庄,050081 |
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| 摘 要： | 以2-氯-3-甲基吡啶为原料,通过高锰酸钾的氧化来制备2-氯烟酸,对影响产率的高锰酸钾和水用量,反应时间,相转移催化剂等作了探讨.通过轮换变量法调优实验,找到了最佳工艺条件,使产率由文献报道的50%提高到65%.
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| 关 键 词： | 2-氯-3-甲基吡啶 2-氯烟酸 高锰酸钾 |
| 文章编号： | 1003-5095（2006）10-0014-03 |
| 收稿时间： | 2006-08-01 |
| 修稿时间： | 2006-08-01 |
Study on Synthetic Technology of 2-Chloro-3-Pyridinecarboxlic acid |
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| NIE Wen-na.Study on Synthetic Technology of 2-Chloro-3-Pyridinecarboxlic acid[J].Hebei Chemical Engineering and Industry,2006,29(10):14-15,18. |
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| Authors: | NIE Wen-na |
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| Affiliation: | Hebei Yanuo Chemical Industry Co., Ltd, Shijiazhuang 050081, China |
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| Abstract: | 2-Chloro-3-pyridinecarboxlic acid was prepared by using 2-chloro-3-methylpyridine as material and potassium permanganate as oxygenate. The factors which affected the rate of product, such as capacity of potassium permanganate and water, time and PCT of the reaction were inquired into. The best condition of the technology was found and the yield rose from 50% reported by the literature to 65% by alternating variable to alternative optima experment. |
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| Keywords: | 2-chloro-3-methylpyridi 2-chloro-3-pyridinecarboxlic acid potassium permanganate |
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