The Release Rate of Indomethacin from Solid Dispersions with Eudragite |
| |
Authors: | Piero De Filippis Monica Boscolo Mario Gibellini Paolo Rupena Fulvio Rubessa |
| |
Affiliation: | a Pharmacy R & D Department, Glaxo Research Laboratories, Verona, Italyb Mariarosa Moneghini Department of Pharmaceutical Sciences, University of Trieste, Trieste, Italy |
| |
Abstract: | The coprecipitates were prepared by a solvent technique using Eudragit E as carrier and indomethacin as a model drug.
X-Ray diffractometry, differential scanning calorimetry (DSC) and wettability tests were employed to investigate the physical state of the studied formulations. Up to 50% of indomethacin can be dispersed in an amorphous state in Eudragit E.
The influence of the pH on the in vitro release of solid dispersions has been evaluated. Because of the good solubility of Eudragit E at pH 1.2 a fast dissolution rate of the drug was observed while a marked delay was noticed at pH 7.5 where the polymer is only permeable to water. At pH 5.8 the kinetics of drug release can be modulated by the drug/polymer ratio. The dissolution rate of the drug can be increased by decreasing its amount in the coevaporate. |
| |
Keywords: | |
本文献已被 InformaWorld 等数据库收录! |
|