In Vivo Skin Permeation of Sodium Naproxen Formulated in Pluronic F-127 Gels: Effect of Azone® and Transcutol® |
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Authors: | Jos Juan Escobar-Ch vez David Quintanar-Guerrero Adriana Ganem-Quintanar |
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Affiliation: | José, Juan Escobar-Chá,vez ,David Quintanar-Guerrero,Adriana Ganem-Quintanar |
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Abstract: | The objective of this study was to determine the penetration of sodium naproxen, formulated in Pluronic F-127 (PF-127) gels containing Azone® and Transcutol® as penetration enhancers, through human skin in vivo. It was found that the combination of Azone® and Transcutol® in PF-127 gels enhanced sodium naproxen penetration, with enhancement ratios of up to two fold compared with the formulation containing only Transcutol®. These results were confirmed by TEWL and ATR-FTIR spectroscopy, suggesting a synergic action for Azone® and Transcutol®. Because of the thermo-reversible behavior of Pluronic gels, the influence of the components added to the gel formulations on viscosity, as a function of temperature, was also studied. |
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Keywords: | Sodium naproxen Transcutol® Azone® PF-127 gel Tape stripping Skin permeation |
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