| 8-羧基吩噻嗪的合成 |
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| 引用本文： | 卢丙成,刘海峰,郑友广,吉民. 8-羧基吩噻嗪的合成[J]. 化工时刊, 2009, 23(11): 32-34. DOI: 10.3969/j.issn.1002-154X.2009.11.009 |
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| 作者姓名： | 卢丙成 刘海峰 郑友广 吉民 |
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| 作者单位： | 东南大学化学化工学院制药工程系,东南大学制药工程研究所,江苏,南京,1210096;东南大学化学化工学院制药工程系,东南大学制药工程研究所,江苏,南京,1210096;东南大学化学化工学院制药工程系,东南大学制药工程研究所,江苏,南京,1210096;东南大学化学化工学院制药工程系,东南大学制药工程研究所,江苏,南京,1210096 |
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| 摘 要： | 以吩噻嗪为原料，经N乙酰化，付克酰基化，去酰基化得到中间体。以总收率78％制得8-羧基吩噻嗪，结构经核磁氢谱（^1H-NMR）、质谱（MS）确证。本方法原料易得，操作简单，总收率较高，而且整个过程不需要柱色谱纯化，适合工业化生产。
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| 关 键 词： | 8-羧基吩噻嗪 抗肿瘤中间体 合成路线 |
Synthesis of 8-phenothiazinecarboxylic Acid |
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| Lu Bingcheng, Liu Haifeng, Zheng Youguang, Ji Min. Synthesis of 8-phenothiazinecarboxylic Acid[J]. Chemical Industry Times, 2009, 23(11): 32-34. DOI: 10.3969/j.issn.1002-154X.2009.11.009 |
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| Authors: | Lu Bingcheng Liu Haifeng Zheng Youguang Ji Min |
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| Affiliation: | 1.Department of Pharmaceutical Engineering;School of Chemistry & Chemical Engineering;Southeast University;Nanjing 210096;China;2.Institute of Pharmaceutical Engineering;China |
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| Abstract: | 8-phenothiazinecarboxylic acid a anticancer drug intermediate.The intermediate was obtained by N-acetylation,Friedel-Crafts acylation,to acylation with phenothiazine as the starting compound.The total yield was 78%.The structure was verified by 1H-NMR and MS.The route was effective,simple and highly productive,and there was no need to use column chromatography in all preparation steps.The process was suitable for industrial applications. |
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| Keywords: | 8-phenothiazinecarboxylic acid anticancer drug intermediate synthetic route |
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