可溶性微针加载化合物的研究进展及特点

可溶性微针是微针中的一大类,现已逐渐成为一种热门的活性物质经皮递送方式。该文主要介绍当前可溶性微针加载小分子化合物种类,包括功能类、治疗类、诊断类及美容类等。通过分类描述在各领域应用的可溶性微针,从不同类化合物的性质分析小分子化合物用可溶性微针加载相较于传统给药制剂的优势,并结合具体微针制备实例来阐述相关进展。总结出可溶性微针加载化合物所应具备的特点,如高活性、高稳定性、使用传统皮肤给药制剂无法达到预期效果、高附加值、与微针的特点相结合等,为其他学者进一步深入研究小分子化合物可溶性微针提供了参考及借鉴。该文也对可溶性微针目前尚未解决的难题,以及未来可能的发展方向作出分析和展望。

Research Progress and Characteristics of the Compounds Loaded in Dissolving Microneedles

The dissolving microneedles have gradually become a popular way of transdermal delivery. This paper mainly introduces all the application areas of dissolving microneedles loaded with small molecule compounds, which are divided into functional categories, treatment, diagnosis and popular cosmetology on the market nowadays.Combining with the specific microneedles preparation examples, the research progress is described by analysing of the small molecule compounds loaded in dissolving microneedle are superior to traditional pharmaceutical preparations from the properties of different compounds in various application fields. It is concluded that compounds loaded in dissolving microneedles should possess the characteristics, such as high activity , high stability, the use of traditional skin preparations can not achieve the desired effect, high additional value and combining with the characteristics of the microneedles, which provides reference for other scholars to further study the small molecule compounds loaded in dissolving microneedles. Finally, the current problems of dissolving microneedles have been put forward and the future trend of dissolving microneedles is forecasted.