高效液相色谱-电感耦合等离子体质谱同时分析鸡肉中洛克沙生、阿散酸和硝苯胂酸

建立一种同时测定鸡肉中洛克沙生、阿散酸和硝苯胂酸等3种有机砷类制剂的高效液相色谱-电感耦合等离子体质谱(high performance liquid chromatography tandem inductively coupled plasma mass spectrometry，HPLC-ICP-MS)分析方法。样品经甲醇溶液提取，采用Phenomenex Luna C18色谱柱，体积分数0.05%的三氟乙酸溶液-甲醇作为流动相进行洗脱，经高效液相色谱分离，电感耦合等离子体质谱进行定性和定量分析。结果表明：1～50μg/kg范围内各砷制剂线性良好，相关系数r2均在0.99以上；在1、2、10μg/kg三个加标水平下进行方法验证，平均回收率为85.4%～103.1%，相对标准偏差为3.3%～7.2%；3种有机砷类制剂的定量限均为1μg/kg。方法重现性好、灵敏度高、前处理简单，各项指标均满足国内外法规要求，适用于鸡肉中有机砷类制剂残留的分析检测。

Simultaneous Determination of Roxarsone,Arsanilic and Nitarsone in Chicken by High Performance Liquid Chromatography/Inductively Coupled Plasma Mass Spectrometry

An analytical method was developed to simultaneously determine roxarsone,arsanilic and nitarsone in chicken by high performance liquid chromatography/inductively coupled plasma mass spectrometry(HPLC-ICP-MS).Samples were extracted with methanol/water solution.The chromatographic separation was performed on a Phenomenex Luna C18 using methanol and water(containing 0.05% trifluoroacetic acid) as the mobile phase.Identification and quantification were achieved by using ICP-MS.Good linearity was observed in the...