植物甾醇酯对高脂血症小鼠的降血脂作用研究

对不同剂量的植物甾醇酯对高脂血症小鼠血脂水平的影响进行研究。饲喂高脂饲料建立小鼠高脂血症模型，然后对小鼠饲喂高脂饲料的同时灌胃不同剂量(50、75、100、125、150mg/(kg ·d))的植物甾醇酯。结果表明：与高脂模型组比较，植物甾醇酯会明显降低血清总胆固醇(TC)和低密度脂蛋白胆固醇(LDL-C)水平，增加高密度脂蛋白胆固醇与低密度脂蛋白胆固醇比值(HDL-C/LDL-C)和HDL-C/TC值，降低动脉硬化指数，对甘油三酯(TG)水平却无明显影响；植物甾醇酯具有调节血脂的作用，高于75mg/(kg ·d)植物甾醇酯可显著降低(P＜0.05)高血脂模型小鼠的血脂水平。

Lipid-lowering Effect of Phytosterol Ester in Hyperlipidemic Rats

In this study, the effect of phytosterol ester at different dosages on serum lipid level of hyperlipidemic mice was investigated. A hyperlipidemic mouse model was established by feeding high fat diet, and then the mice were administered with phytosterol ester at the dosages of 50, 75, 100, 125 mg/(kg ·d) and 150 mg/(kg ·d), respectively. The results showed that phytosterol ester could significantly reduce total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and arteriosclerosis index (AI) through increasing HDL-C/LDL-C and HDL-C/TC index when compared with hyperlipidemic group. However, no significant effect of phytosterol ester on triglyceride (TG) level was observed. In addition, phytosterol ester could regulate serum lipid level at the dose of 75 mg/(kg ·d) for phytosterol ester (P＜0.05).