A test of the effects of pregnenolone methyl ether on subjective feelings of B-29 crews after a twelve-hour mission.

Members of 7 B-29 crews received PME (experimental = 51) or a placebo (controls = 49) and took a group of psychological tests measuring manifest irritability, anxiety, and fatigue reactions, after a long (15-18 hours) over-water training mission. The tests were administered both before the drug administration (immediately upon landing) and after unloading the planes (which followed drug administration). Although there were significant pre-test and post-test differences for each group, there were no significant inter-group differences. "This study does not support the use of PME for the alleviation of depression, irritability and anxiety feelings of crew members." (PsycINFO Database Record (c) 2010 APA, all rights reserved)