| 离子液体中采用AGET ATRP法制备MCC-g-PGMA |
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| 引用本文： | 袁淼,唐二军,杜凯迪,刘洪,周剑,刘少杰,赵地顺.离子液体中采用AGET ATRP法制备MCC-g-PGMA[J].化工学报,2015,66(Z1):365-369. |
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| 作者姓名： | 袁淼 唐二军 杜凯迪 刘洪 周剑 刘少杰 赵地顺 |
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| 作者单位： | 河北科技大学化学与制药工程学院, 河北省药物化工工程技术中心, 河北 石家庄 050018 |
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| 基金项目： | 国家自然科学基金项目，河北省自然科学基金项目(B2013208183).supported by the National Natural Science Foundation of China，the Natural Science Foundation of Hebei Province |
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| 摘 要： | 在氯化1-烯丙基-3-甲基咪唑(AMIM]Cl)离子液体中,采用AGET ATRP技术,以VC为还原剂、Cu Br2/乙二胺为催化体系,成功制备了微晶纤维素接枝聚甲基丙烯酸缩水甘油酯(MCC-g-PGMA)分子。研究表明:AMIM]Cl对微晶纤维素有较好的溶解性,最佳反应条件为GMA/乙二胺/Cu Br2/VC摩尔比为100:4:1:1,反应温度25℃,反应时间4 h,接枝效率可达54.56%,分子量分布较窄为1.48。通过FT-IR、TEM和SEM测试表明:成功合成了MCC-g-PGMA接枝共聚物分子,PGMA接枝微晶纤维素后表面形态变得粗糙,接枝共聚物在丙酮溶液中可自组装成150~200 nm的球形结构,在药物载体领域具有良好的应用潜能。
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| 关 键 词： | 离子液体 甲基丙烯酸缩水甘油酯 AGET ATRP 微晶纤维素 分子合成 聚合物 |
| 收稿时间： | 2014-12-15 |
| 修稿时间： | 2014-12-24 |
Synthesis of MCC-g-PGMA by AGET ATRP in ionic liquids |
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| YUAN Miao,TANG Erjun,DU Kaidi,LIU Hong,ZHOU Jian,LIU Shaojie,ZHAO Dishun.Synthesis of MCC-g-PGMA by AGET ATRP in ionic liquids[J].Journal of Chemical Industry and Engineering(China),2015,66(Z1):365-369. |
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| Authors: | YUAN Miao TANG Erjun DU Kaidi LIU Hong ZHOU Jian LIU Shaojie ZHAO Dishun |
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| Affiliation: | School of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Hebei Research Center of Pharmaceutical and Chemical Engineering, Shijiazhuang 050018, Hebei, China |
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| Abstract: | The MCC-g-PGMA was synthesized by AGET ATRP in ionic liquid AMIM]Cl. Vitamin C was used as the reducing agent and CuBr2/ethanediamine was the catalytic system. The experiment proved that microcrystalline cellulose can well dissolve in AMIM]Cl. Optimum mole ratio of GMA/ethanediamine/ CuBr2/VC were attained at 100:4:1:1. The temperature and reaction time were 25℃ and 4 h. The grafting efficiency was as high as 54.56% and the distribution of molecular weight of MCC-g-PGMA was 1.48. FT-IR proved that the MCC-g-PGMA graft copolymer was successfully synthesized by AGET ATRP in AMIM]Cl. SEM showed the surface of MCC was changed and became coarse after PGMA grafted to MCC. It has a perfect application potential in the field of drug carrier. |
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| Keywords: | ionic liquid methyl methacrylate AGET ATRP microcrystalline cellulose molecular synthesis polymers |
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