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Alkoxy Tetrazine Substitution at a Boron Center: A Strategy for Synthesizing Highly Fluorogenic Hydrophilic Probes |
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| Authors: | Dr Min Wu Dr Xiaoai Wu Yayue Wang Lei Gu Jiao You Prof Haoxing Wu Prof Ping Feng |
| Affiliation: | 1. Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, West China Medical School, Sichuan University, Chengdu, P.R. China;2. Department of Nuclear Medicine, West China Hospital, Sichuan University, Sichuan, P.R. China;3. Institute of Clinical Trials, West China Hospital, Sichuan University, Chengdu, Sichuan, P.R. China |
| Abstract: | Strongly fluorogenic boron dipyrromethene (BODIPY)–tetrazine probes have been obtained by introducing an alkoxy tetrazine fragment at the boron center. The fluorescence signal from these probes strongly increases by up to 225‐fold after reaction with bioorthogonal coupling partners, and the hydrophilicity of probes is improved, such that they are suitable for live‐cell imaging. |
| Keywords: | bioorthogonal chemistry dyes/pigments fluorescent probes imaging agents tetrazines |