现代色谱技术在天然产物研究中的应用

天然产物来源广泛、种类繁多、结构复杂且多数未知。随着人们对天然产物认识的深入以及仪器分析检测技术的进步，天然产物的开发与利用日益受到重视。近年来发展的新型色谱模式、色谱-质谱联用、谱效关联等现代色谱技术不但促进了天然产物的分离检测与纯化制备，同时推动了天然产物活性物质的阐明，加快了天然产物研究的步伐。基于上述现代色谱技术，本文结合文献主要从分析检测、分离制备、活性筛选这3个层面综述其在天然产物活性物质研究方面的应用，以期为进一步发展色谱技术在天然产物的开发与利用中提供一定的参考依据，希望通过本文的研究可以促进色谱技术在天然产物活性成分提取与纯化领域的快速发展。

Application of modern chromatography technology in natural products research

The natural products have a wide range of sources, various kinds, complex structures and most of them are unknown. With the deepening of people''s understanding of natural products and the progress of instrumental analysis and detection technology, the development and utilization of natural products have been paid more and more attention. In recent years, the development of modern chromatographic technologies such as new chromatographic mode, chromatography-mass spectrometry, chromatographic-effect correlation that not only promoted the separation, detection, purification and preparation of natural products, but also promoted the elucidation of active substances in natural products, and accelerated the pace of natural products research. Based on the above modern chromatographic technology, this paper reviewed its application in the research of active substances in natural products from three aspects of detection, preparation and screening methods, so as to provide some reference for the further development of chromatographic technology in the development and utilization of natural products.