| 平贝母雪梨配伍抗炎作用研究 |
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| 引用本文： | 李霞,高文远,黄丽晶,张艳军. 平贝母雪梨配伍抗炎作用研究[J]. 食品科学, 2010, 31(1): 235-239. DOI: 10.7506/spkx1002-6630-201001055 |
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| 作者姓名： | 李霞 高文远 黄丽晶 张艳军 |
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| 作者单位： | 1.天津大学药物科学与技术学院 2.天津中医药大学中药学院 |
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| 摘 要： | 目的：观察平贝母水提物、雪花梨汁以及平贝雪梨饮(BLY)的抗炎作用及其作用机制。方法：通过二甲苯导致小鼠耳肿胀实验、鸡蛋清致大鼠足趾肿胀实验及对小鼠毛细血管通透性的影响分别观察平贝母水提物、雪花梨及BLY 的抗炎作用，同时通过测定小鼠炎性渗出物中前列腺素(PGE2)和丙二醛(MDA)含量研究三者的抗炎机制。结果：三者均能减轻二甲苯所致的耳廓肿胀；能降低小鼠毛细血管通透性；能减轻鸡蛋清致大鼠足趾肿胀；能抑制小鼠炎性渗出物中PGE2 和MDA 含量的升高，且梨汁和BLY 均与PGE2 和MDA 含量呈量效关系。结论：平贝母水提物和雪花梨汁都具有抗炎作用，同等剂量的BLY 作用效果比平贝母水提物和雪花梨汁抗炎作用之和更为显著，三者对PGE2 和MDA 含量升高具有负调节作用，提示其抗炎作用与抗PGE2 和MDA 含量升高有关。
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| 关 键 词： | 平贝母水提物 雪花梨汁 平贝雪梨饮(BLY) 抗炎作用 |
| 收稿时间： | 2009-03-05 |
Anti-inflammatory Effect of Fritillaria ussuriensis Maxim.Combined with Snow Pear Juice |
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| LI Xia,GAO Wen-yuan,HUANG Li-jing,,ZHANG Yan-jun. Anti-inflammatory Effect of Fritillaria ussuriensis Maxim.Combined with Snow Pear Juice[J]. Food Science, 2010, 31(1): 235-239. DOI: 10.7506/spkx1002-6630-201001055 |
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| Authors: | LI Xia GAO Wen-yuan HUANG Li-jing ZHANG Yan-jun |
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| Affiliation: | (1. School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China；2. School of Chinese Medicine,Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China) |
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| Abstract: | Objective:To investigate anti-inflammatory effects and action mechanisms of aqueous extract of Fritillaria ussuriensis Maxim.,snow pear juice and Pingbei Xueli Yin(BLY).Methods:Animal models of auricular edema induced by xylene in mice,capillary permeability induced by acetic acid in mice and paw edema induced by albumen in rats were established to observe anti-inflammatory effects of aqueous extract of Fritillaria ussuriensis Maxim.,snow pear juice and BLY.The contents of PGE2 and MDA in inflammatory exuda... |
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| Keywords: | aqueous extract of Fritillaria ussuriensis Maxim. snow pear juice BLY anti-inflammatory effect |
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