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Paf-acether in human skin
Authors:Yves Denizot  Laurence Michel  Jacques Benveniste  Alain Meybeck  Yolène Thomas  Louis Duberfret
Affiliation:(1) INSERM U.312, 92010 Crèteil, France;(2) LVMH Recherche, 92704 Colombes, France;(3) Present address: Faculté de Médecine, C.J.F. INSERM 88-03, 2 rue du Docteur Marcland, 87025 Limoges, France;(4) INSERUM U.200, 32 rue des Carnets, 92140 Clamart, France
Abstract:Paf is a phospholipid mediator present in human skin which induces inflammatory events such as neutrophil infiltration and increased vascular permeability. Recent data suggest that cutaneous cells, such as fibroblasts and keratinocytes, produce paf and that paf is released during allergic cutaneous reactions. It is tempting to speculate that paf may contribute to the development of various skin disorders with acute and chronic skin inflammation. Paf antagonists may help in bringing answers to this hypothesis and may offer new prospects for the treatment of cutaneous inflammatory diseases. Based on a paper presented at the Third International Conference on Platelet-Activating Factor and Structurally Related Alkyl Ether Lipids, Tokyo, Japan, May 1989.
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