Paf-acether in human skin |
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Authors: | Yves Denizot Laurence Michel Jacques Benveniste Alain Meybeck Yolène Thomas Louis Duberfret |
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Affiliation: | (1) INSERM U.312, 92010 Crèteil, France;(2) LVMH Recherche, 92704 Colombes, France;(3) Present address: Faculté de Médecine, C.J.F. INSERM 88-03, 2 rue du Docteur Marcland, 87025 Limoges, France;(4) INSERUM U.200, 32 rue des Carnets, 92140 Clamart, France |
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Abstract: | Paf is a phospholipid mediator present in human skin which induces inflammatory events such as neutrophil infiltration and
increased vascular permeability. Recent data suggest that cutaneous cells, such as fibroblasts and keratinocytes, produce
paf and that paf is released during allergic cutaneous reactions. It is tempting to speculate that paf may contribute to the
development of various skin disorders with acute and chronic skin inflammation. Paf antagonists may help in bringing answers
to this hypothesis and may offer new prospects for the treatment of cutaneous inflammatory diseases.
Based on a paper presented at the Third International Conference on Platelet-Activating Factor and Structurally Related Alkyl
Ether Lipids, Tokyo, Japan, May 1989. |
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Keywords: | |
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