| 聚甘油接枝改性琥珀酸单胆固醇酯的研究 |
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| 引用本文： | 王丽仙,娄江豪,朱丽丽,应玲龙,李英龙,刘廷先,严晓阳. 聚甘油接枝改性琥珀酸单胆固醇酯的研究[J]. 浙江化工, 2014, 0(1): 23-25 |
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| 作者姓名： | 王丽仙 娄江豪 朱丽丽 应玲龙 李英龙 刘廷先 严晓阳 |
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| 作者单位： | 浙江师范大学化学与生命科学学院;浙江师范大学行知学院 |
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| 摘 要： | 以二甲苯为溶剂，对甲苯磺酸为催化剂，用聚甘油对脂质体琥珀酸单胆固醇酯酯化反应的方法接枝改性。通过正交试验考察了催化剂、反应时间及投料比等对收率的影响，结果表明：n（胆固醇单琥珀酸酯）：n（二聚甘油）=1：1.2，反应时间为3 h，催化剂的用量为胆固醇单琥珀酸酯质量的15%，聚甘油胆固醇琥珀酸酯的收率可达66%。并用红外光谱对产品的化学结构进行表征。
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| 关 键 词： | 聚甘油 接枝改性 琥珀酸单胆固醇酯 聚甘油琥珀酸胆固醇酯 |
Reserch on Polygelycerol Grafting Modification for Cholesteryl Hemisuccinate |
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| WANG Li-xian;LOU Jiang-hao;ZHU Li-li;YING Ling-long;LI Ying-long;LIU Ting-xian;YAN Xiao-yang. Reserch on Polygelycerol Grafting Modification for Cholesteryl Hemisuccinate[J]. Zhejiang Chemical Industry, 2014, 0(1): 23-25 |
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| Authors: | WANG Li-xian LOU Jiang-hao ZHU Li-li YING Ling-long LI Ying-long LIU Ting-xian YAN Xiao-yang |
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| Affiliation: | WANG Li-xian;LOU Jiang-hao;ZHU Li-li;YING Ling-long;LI Ying-long;LIU Ting-xian;YAN Xiao-yang;College of Chemistry and Life Science,Zhejiang Normal University;Xingzhi College,Zhejiang Normal University; |
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| Abstract: | The cholesteryl hemisuccinate was grafting modified with polyglycerol using p-TSA as catalyst, dimethylbenzene as solvent. The effects of catalyst dosage, reaction time and mole ratio of raw material on the product were investigated. It was found as follow：reaction time 3 h, mole ratio of polyglycerol to cholesteryl hemisuccinate 1.2 and p-TSA dosage 15% of the mass of cholesteryl hemisuccinate.Under the condition,the yield of product was up to 66%.The chemical structure and physical properties were tested by FT-IR and melting point. |
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| Keywords: | polyglycerol grafting modification cholesteryl hemisuccinate polyglycerol cholesteryl succinate |
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