不同强度脉冲电磁场对去卵巢大鼠股骨骨密度的影响

目的：建立去卵巢大鼠骨质疏松模型，通过采用不同治疗强度脉冲电磁场（PEMFs）干预去卵巢大鼠，观察各组大鼠的股骨骨密度的变化，初步确定治疗骨质疏松的最适的治疗强度。方法：按随机的分组原则用密闭信封法将雌性3月龄sD大鼠50只分为5组：SHAM对照组10只、OVX对照组10只、OVXⅠ组10只、OVXⅡ组10只、OVXⅢ...

Effect of pulsed electromagnetic fields of different intensity on bone mineral density of femur in ovariectomized rats

Objective：The purpose of this study was to observe the effect of different treatment intensity of pulsed electromagnetic fields（ PEMFs） on bone mineral density of femur in ovariectomized rats, so as to find out the treatment intensity for the best therapeutic efficacy. Methods： Fifty female SD rats were randomly divided into five groups： （ 1 ） sham - operated control （ no PEMFs treatment）, （ 2 ） ovariectomized control （ no PEMFs treatment ）,（3 ） ovariectomized I （ PEMFs treatment at 8Hz frequency with 0.77mT intensity, 40min daily for 30days）, （4） ovariectomized II （PEMFs treatment at 8Hz frequency with 3.82mT intensity, 40min daily 30 days）, and （5） ovariectomized Ill （PEMFs treatment at 8Hz frequency with 9.87mT intensity, 40min daily 30 days）. Except for 10 rats of the sham - operated control group, a standardized ovariectomy was used in every rat. Estradiol （ E2） of serum and bone mineral density of femur were assessed at 30 days after PEMFs treatment. Results： The bone mineral density of the OVXo control group were significantly lower than the other 4 groups （P 〈 0.05 or P 〈 0.01 ）, but the difference in bone mineral density was not significant among the other 4 groups （ P 〉 0. 05 ）. that means OVX 1 , OVX II , OVX III groups can prevent bone mineral density of femur . Conclusion： 0. 77mT -9.87mT magnetic intensity can prevent bone mineral density of femur ovariectomized rats effectively.