烷基化壳聚糖/多巴胺/氧化石墨烯粉末用于快速止血

壳聚糖（CS）及其衍生物价廉易得,止血性及生物相容性良好,广泛应用于抗菌、止血等材料的开发。使用十二醛对CS进行N-烷基化改性制备烷基化壳聚糖（N-CS）,并在乙酸溶液中将N-CS嵌入到多巴胺修饰的氧化石墨烯（DGO）骨架中制备新型的止血粉末（N-CS/DGO）。FTIR,SEM和BET等表明N-CS/DGO止血粉末表面含有大量的活性基团,且具有优异的亲水性,大比表面积以及丰富的孔结构。DGO占比为15%具有最佳止血潜力,此时材料的吸水率为430%,降解速度适宜,五周达到88%,对大肠杆菌和金黄色葡萄球菌抑菌圈分别为1.92 mm、1.98 mm,具备一定抑菌能力,凝血指数达到最小值32%,体外凝血时间缩短至126±6 s,这些都表明N-CS/DGO材料具备止血方面的潜力。

Alkylated chitosan/dopamine/graphene oxide power for rapid hemostasis

Due to its low price and availability, good hemostasis and biocompatibility, chitosan (CS) and its derivatives are widely used in the development of antibacterial and hemostatic materials. Alkylated chitosan (N-CS) was prepared by N-alkylation modification of CS with dodecanal and embedding N-CS into the polydopamine-modified graphene oxide (DGO) framework in acetic acid solution to prepare novel hemostatic powders (N-CS/DGO). The structure and morphology were characterized by FTIR, SEM and BET, which indicated that the surface of N-CS/DGO hemostatic powder contained a large number of active groups, and had excellent hydrophilicity, large specific surface area and rich pore structure. When DGO account for 15%, the composite power had the best potential for hemostasis. At this time, the material could absorb water by 430% over itself , and the degradation ratio was appropriate, reaching 88% in five weeks. The inhibition zones for E. coli and S. aureus were 1.92 mm and 1.98 mm, respectively. With certain bacteriostatic ability, the coagulation index could reach its minimum, that was 32%, and the in vitro coagulation time was shortened to 126± 6 s, all of which indicated that N-CS / DGO materials had potential for hemostasis.