| 6Gy全身辐射对大鼠伤口巨噬细胞功能的影响 |
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| 引用本文： | 宋述强,程天民.6Gy全身辐射对大鼠伤口巨噬细胞功能的影响[J].辐射研究与辐射工艺学报,1997,15(3):175-178. |
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| 作者姓名： | 宋述强 程天民 |
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| 作者单位： | 第三军医大学全军复合伤研究所 |
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| 摘 要： | 以在鼠背部置入聚乙烯醇海绵的切口伤为模型，研究了６Ｇｙ全身辐射对伤口巨噬细胞功能的影响。结果表明在辐射后３、５、８ｄ的伤口不但巨噬细胞数量明显下降，而且巨噬细胞的吞噬功能，ＴＮＦα和ＩＬ－１的释放以及对伤口成纤维细胞增殖的调节能力都明显下降，说明了创伤愈合早期伤口巨细胞数量和功能的下降是辐射造成愈合延迟的重要原因。
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| 关 键 词： | 巨噬细胞 创伤愈合 6Gy 辐射效应 全身辐射 |
THE EFFECTS OF 6Gy WHOLEBODY IRRADIATION ON WOUND MACROPHAGE FUNCTION |
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| Song Shuqiang,Cheng Tianmin.THE EFFECTS OF 6Gy WHOLEBODY IRRADIATION ON WOUND MACROPHAGE FUNCTION[J].Journal of Radiation Research and Radiation Processing,1997,15(3):175-178. |
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| Authors: | Song Shuqiang Cheng Tianmin |
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| Abstract: | Macrophages play an important role in wound healing The effects of 6Gy whole body irradiation on wound macrophage function was studied by a rat dorsum incision in which polyvinyl alcohol sponges were implanted It was found that the phagocytic activity, the release of tumor necrosis factor and interleukin 1, the regulatory effect on wound fibroblast proliferation by wound macrophages, as well as the number of macrophages in wound, were significantly decreased on day 3, 5, 8 after wounding The results indicated that the important mechanism of depression of wound healig after whole body irradiation is the decrease in number and impairment of function of wound macrophages in the early stage of wound healing |
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| Keywords: | Irradiation Wound healing Macrophages |
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