| 乙基纤维素-艾叶粉溶液微胶囊的制备 |
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| 引用本文： | 张扬,杨子明,邓思贤,杨卓鸿,李鹂,欧韦文,汪国成.乙基纤维素-艾叶粉溶液微胶囊的制备[J].广东化工,2009,36(5):6-8. |
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| 作者姓名： | 张扬 杨子明 邓思贤 杨卓鸿 李鹂 欧韦文 汪国成 |
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| 作者单位： | [1]华南农业大学理学院,广东广州510642 [2]香港理工大学护理学院,香港九龙 |
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| 基金项目： | 广东省科技攻关计划项目（2006813801004）,人事部留学归国资助项目,香港理工大学资助项目 |
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| 摘 要： | 文章首次以乙基纡维素为壁材，采用溶剂蒸发法制得艾叶粉水溶液微胶囊。正交实验得出制备微胶囊的最佳工艺条件为：乙基纤维素：芯材：乙酸乙酯：水相=1：25：13：130（质量比），搅拌速度：1500r／min，乳化时间：15mim，水油两相混合搅拌时间：10min。通过扫描电镜表征结果显示，所得微胶囊固体颗粒呈球形，分散性好，粒径在20-200μm范围内。实验制得微胶囊最大载药量为48．07％，具有良好的包覆效果。透析缓释实验表明，微胶囊在3.0℃恒温生理盐水浸泡60h后，仍有艾叶药理活性成分存在，较好地延长了储藏时间和药物有效作用时限。
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| 关 键 词： | 乙基纤维素 艾叶粉溶液 微胶囊 缓释 |
Preparation and Controlled-release Study of Ethyl Cellulose-moxa Leaf Powder Solution Microcapsules |
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| Affiliation: | Zhang Yang, Yang Ziming, Deng Sixian, Yang Zhuohong, Lily, Ou Waiman, Thomas K.S. Wong (1. South China Agriculture University, College of Science, Guangzhou, 510642, China; 2. Hong Kong Polytechnic University, College of Nursing, Hong Kong) |
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| Abstract: | In the paper, moxa leaf powder solution microcapsules were firstly prepared by solvent evaporation method with ethyl cellulose as shell material. Orthogonal experiments showed that the best processing conditions of the microcapsules was： ethyl cellulose ： sandwich material ： ethyl acetate ： aqueous phase=1 ： 2.5 ： 13 ： 130（mass ratio）, stirring at 1500 r/min, dispersed of 15 min, water/oil mixed of 10 min. Scanning electron microscopy（SEM）were used to characterize of microcapsules. The particle size wad spherical, dispersibility and diameters of 20-200 μm. Microcapsules allowed a better encapsulation of moxa leaf powder solution and the best drug load was 48.07 %. The controlled-release experiment proved that after immersing in normal saline for 60 h under constant temperature of 37 ℃, the activity of moxa leaf powder solution was preserved. |
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| Keywords: | ethyl cellulose moxaleafpowdersolution microcapsules controlled-release |
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