| 3,5-二甲氧基邻苯二甲酸酐的合成与表征 |
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| 引用本文： | 杜杨,孙小莉,刘祖亮,吕春绪.3,5-二甲氧基邻苯二甲酸酐的合成与表征[J].精细化工,2007,24(8):826-828. |
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| 作者姓名： | 杜杨 孙小莉 刘祖亮 吕春绪 |
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| 作者单位： | 南京理工大学,化工学院,江苏,南京,210094 |
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| 摘 要： | 3,5-二甲氧基苯甲酸与水合氯醛进行烷基化和成环反应生成(4,6-二甲氧基-7-三氯甲基)-2-苯并c]呋喃酮,然后经水解、脱羧、氧化、脱水反应合成了3,5-二甲氧基邻苯二甲酸酐,反应总得率78%。反应的中间物和目标产物用IR,1HNMR和MS等进行了表征。用该化合物合成取代蒽醌、金丝桃素及其衍生物的研究正在进行中。
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| 关 键 词： | 金丝桃素 3 5-二甲氧基邻苯二甲酸酐 3 5-二甲氧基苯甲酸 水合氯醛 |
| 文章编号： | 1003-5214（2007）08-0826-03 |
| 修稿时间： | 2006-11-22 |
Synthesis and Characterization of 3,5-Dimethoxyphthalic Anhydride |
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| DU Yang,SUN Xiao-li,LIU Zu-liang,L Chun-xu.Synthesis and Characterization of 3,5-Dimethoxyphthalic Anhydride[J].Fine Chemicals,2007,24(8):826-828. |
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| Authors: | DU Yang SUN Xiao-li LIU Zu-liang L Chun-xu |
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| Affiliation: | School of Chemical Engineering, Nanjing University of Science and Technology, Nanfing 210094, Jiangsu, China |
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| Abstract: | The alkylation and annulation reactions of methyl 3,5-dimethoxybenzoate with chloral hydrate produced 4,6-dimethoxy-7-trichloromethyl-phthalide.Then the obtained compound was hydrolyzed,decarboxylated,oxidized and dehydrated subsequently to synthesize 3,5-dimethoxyphthalic anhydride in total yield of 78%.The objective and intermediate compounds were characterized by IR,1HNMR and MS.The researches using title compound to synthesize substituted anthraquinones,hypericin and its derivatives are in operation. |
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| Keywords: | hypericin 3 5-dimethoxyphthalic anhydride methyl 3 5-dimethoxybenzoate chloral hydrate |
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