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| 乌头碱、中乌头碱、次乌头碱及水解产物的电喷雾质谱裂解机制研究 | |
| 引用本文： | 李铮,谭鹏,王春国,刘永刚,陈鑫. 乌头碱、中乌头碱、次乌头碱及水解产物的电喷雾质谱裂解机制研究[J]. 现代仪器, 2011, 17(2) |
| 作者姓名： | 李铮 谭鹏 王春国 刘永刚 陈鑫 |
| 作者单位： | 1. 北京市药品审评中心,北京,100053 2. 北京中医药大学中药学院,北京,00102 3. 北京大学医学部药学院,北京,100191 |
| 摘 要： | 目的:研究乌头碱、中乌头碱和次乌头碱及其水解产物的质谱裂解机制。方法:采用直接进样(FAB)-电喷雾(ESI)-质谱(MS)的方法,在正离子模式下对3种双酯碱和其水解产物进行了多级质谱检测。结果:均产生了[M+H]~+准分子离子,裂解过程中以失掉水,甲醇,一氧化碳中性分子为主。结论:该数据有利于进一步研究乌头属生物碱的化学成分和质量标准的建立。 |
| 关 键 词： | 质谱 水解产物 乌头碱 中乌头碱 次乌头碱 |
The ESI-MS study on the fragmentation pathways of the aconitine,mesaconitine,hypaconitine and their hydrolyzates |
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| Li Zheng,Tan Peng,Wang Chunguo,Liu Yonggang,Chen Xin. The ESI-MS study on the fragmentation pathways of the aconitine,mesaconitine,hypaconitine and their hydrolyzates[J]. Modern Instruments, 2011, 17(2) | |
| Authors: | Li Zheng Tan Peng Wang Chunguo Liu Yonggang Chen Xin |
| Abstract: | Objective To study the MS fragmentation Pathways of the aconitine,mesaconitine, hypaconitine and their hydrolyzates.Methods The fragmentation pathways were analyzed by electrospray ionization mass spectrometry,ESI MS/MS,under positive mode. Their quasi-molecular ions were all[M+H]~+,their common occurrence of losing CO_2, H_2O,HF and CO were discovered.Result The profiles of fragments will be usefull to set quality criteria and to study chemical composition of aconitum alkaloids |
| Keywords: | MS Hydrolyzates Aconitine Mesaconitine Hypaconitine |
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