Type VIII collagen |
| |
Authors: | CA Shuttleworth |
| |
Affiliation: | University of Manchester, Wellcome Trust Centre for Cell-matrix Research, U.K. |
| |
Abstract: | Type VIII collagen is a product of endothelial cells, keratinocytes, mast cells, microvascular endothelial cells and some tumour cells. It is also present in a variety of extracellular matrices as diverse as sclera, skin and glomerulus. Type VIII molecules have a proposed chain composition of alpha 1(VIII)2 alpha 2(VIII)]. While the function of collagen type VIII is uncertain recent work has highlighted the importance of this collagen in the vasculature. Particularly significant may be its up-regulation in smooth muscle cell migration and potential role in maintaining the smooth muscle cell phenotype. It is interesting to speculate that this collagen may provide a substratum for a variety of cells and facilitate movement of endothelial cells in angiogenesis, smooth muscle cells in intimal invasion and myofibroblasts in fibrotic conditions. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|