| 大孔磺酸树脂催化合成7-羟基-4-甲基香豆素 |
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| 引用本文： | 胡云楚.大孔磺酸树脂催化合成7-羟基-4-甲基香豆素[J].精细化工,2010,27(10). |
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| 作者姓名： | 胡云楚 |
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| 作者单位： | 中南林业科技大学,应用化学研究所,湖南,长沙,410004 |
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| 基金项目： | 湖南省研究生科研创新基金项目 |
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| 摘 要： | 考察了DT-852大孔磺酸树脂催化合成7-羟基-4-甲基香豆素的工艺。结果表明,DT-852大孔磺酸树脂具有较好的催化活性;7-羟基-4-甲基香豆素较佳的合成工艺为:反应温度105℃,反应时间2.5h,催化剂用量1.0g,物料比n(乙酰乙酸乙酯)∶n(间苯二酚)=1∶1,产率为93.8%,w(7-羟基-4-甲基香豆素)=98.3%(HPLC),催化剂可重复使用多次。产物结构经FTIR验证。
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| 关 键 词： | 大孔磺酸树脂 催化合成 香豆素 精细化工中间体 |
| 收稿时间： | 5/5/2010 12:00:00 AM |
| 修稿时间： | 2010/6/18 0:00:00 |
Synthesis of 7-hydroxy-4-methyl coumarin catalyzed by macroporous sulfoacid resin |
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| HU Yun-chu.Synthesis of 7-hydroxy-4-methyl coumarin catalyzed by macroporous sulfoacid resin[J].Fine Chemicals,2010,27(10). |
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| Authors: | HU Yun-chu |
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| Abstract: | 7-hydroxy-4-methyl coumarin is an important chemical intermediate. DT-852 macroporous sulfonic acid resin is developed as efficient catalyst in synthesis of 7-hydroxy-4-methyl coumarin technology. Results show: DT-852 macroporous sulfonic acid resin has well catalytic activity; The better synthesis conditions for 7-hydroxy-4-methyl coumarin were: reaction temperature 105 oC and reaction time 2.5 h, 1.0 g catalyst, material ratio ethyl acetoacetate to resorcinol 1.0, the yield was 93.8%, w (7-hydroxy-4-methyl coumarin) = 98.27% (HPLC). Catalyst can be reused many times. Product was verified with mp and IR. |
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| Keywords: | Macroporous sulfoacid resin catalyst synthesis coumarin |
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