| 硫酸头孢匹罗的合成 |
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| 引用本文： | 宋艳玲,王晓欢,姜璐璐,孟艳秋.硫酸头孢匹罗的合成[J].沈阳化工学院学报,2011,25(3). |
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| 作者姓名： | 宋艳玲 王晓欢 姜璐璐 孟艳秋 |
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| 作者单位： | 1. 沈阳化工大学化学工程学院,辽宁沈阳,110142
2. 中油辽河工程有限公司油气加工所,辽宁盘锦,124010 |
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| 摘 要： | 7-ACA和MAEM在三乙胺和吡啶的催化作用下缩合得到头孢噻肟酸,头孢噻肟酸在六甲基二硅烷和碘条件下与2,3-环戊烯并吡啶发生取代反应,得到头孢匹罗二氢碘酸盐,再经过新型离子交换树脂进行转盐反应,获得最终产品硫酸头孢匹罗,总收率为63%（以7-ACA计）.目标化合物结构经核磁共振氢谱及质谱确证.
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| 关 键 词： | 头孢匹罗 抗生素 合成 改进 |
Synthesis of Cefpirome Sulfate |
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| Abstract: | Cefotaxime,which was prepared from 7-ACA and MAEM in triethylamine and pyridine,was subsequently reacted with 2,3-cyclopenopyridine in the presence of hexamethyldisilazane and iodine to give cefpirome dihydroiodide.It was further treated that new ion exchange resin was afforded the target compound cefpirome sulfate in 63 % overall yield（based on 7-ACA）.Structure of the target compound was confirmed by 1H-NMR and MS. |
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| Keywords: | cefpirome antibiotics synthesis improvement |
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