| 紫杉醇C-13侧链的合成进展 |
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| 引用本文： | 吝保瑞,冯霞,徐芳. 紫杉醇C-13侧链的合成进展[J]. 化学试剂, 2006, 28(8): 461-464 |
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| 作者姓名： | 吝保瑞 冯霞 徐芳 |
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| 作者单位： | 天津大学,理学院,天津,300072;天津大学,理学院,天津,300072;天津大学,理学院,天津,300072 |
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| 摘 要： | (2R,3S)-N-苯甲酰基-3-苯基异丝氨酸是合成抗癌药物紫杉醇的重要原料,它的制备方法反映出手性物质的一些特点和发展方向。本文从化学法和生物酶法两方面综述了该物质的合成方法,并对其中一些有代表性和应用前景的方法进行了重点介绍。
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| 关 键 词： | 紫杉醇 侧链 不对称催化 酶催化 |
| 文章编号： | 0258-3283（2006）08-0461-04 |
| 收稿时间： | 2006-01-26 |
| 修稿时间： | 2006-01-26 |
Advances in synthesis of taxol C-13 side chain: N-benzoyl-(2R,3S)-3-phenylisoserine |
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| LIN Bao-rui,FENG Xia,XU Fang. Advances in synthesis of taxol C-13 side chain: N-benzoyl-(2R,3S)-3-phenylisoserine[J]. Chemical Reagents, 2006, 28(8): 461-464 |
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| Authors: | LIN Bao-rui FENG Xia XU Fang |
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| Affiliation: | Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, China |
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| Abstract: | N-benzoyl-(2R,3S)-3-phenylisoserine is a key material in the semi-synthesis of anticancer drug taxol.The preparation of this chiral serine analog may reveal the characteristics and progress in the development of chiral materials.The chemical and biological methods to prepare N-benzoyl-(2R,3S)-3-phenylisoserine were reviewed.Special emphases were laid on the most representative and promising ones. |
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| Keywords: | taxol side chain asymmetric catalysis enzymatic catalysis |
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