| 点击化反应合成8-(4-苯基-1,2,3-三氮唑)-喹啉 |
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| 引用本文： | 张慧梓,范逸平. 点击化反应合成8-(4-苯基-1,2,3-三氮唑)-喹啉[J]. 化工时刊, 2011, 25(2): 39-41. DOI: 10.3969/j.issn.1002-154X.2011.02.011 |
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| 作者姓名： | 张慧梓 范逸平 |
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| 作者单位： | 云南民族大学,民族药资源国家重点实验室,云南,昆明,650500 |
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| 摘 要： | 以喹啉为原料,经改进Skraup法合成了8-羟基喹啉,再合成8-氯喹啉,最终利用点击反应,合成总产物.采用相转移催化剂,水作为溶剂和价廉的Cu(I)为催化剂,常温下-锅制得产物,并且产率高达90%.
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| 关 键 词： | 8-(4-苯基-1,2,3-三氮唑)-喹啉 点击化学 合成 |
Synthesis of 8-(4-phenyl-1H-1,2,3-triazol-1-y1) Quinoline with Click Chemistry |
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| Zhang Huizi,Fan Yiping. Synthesis of 8-(4-phenyl-1H-1,2,3-triazol-1-y1) Quinoline with Click Chemistry[J]. Chemical Industry Times, 2011, 25(2): 39-41. DOI: 10.3969/j.issn.1002-154X.2011.02.011 |
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| Authors: | Zhang Huizi Fan Yiping |
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| Affiliation: | Zhang Huizi Fan Yiping(YunNan Nationnalities University,Key Laboratory of National Medicine Resources, Yunnan Kunming 650500) |
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| Abstract: | Quinoline as raw materials,Synthesis of 8-hydroxyquinoline by improved Skraup method,and then synthesis of 8-chloroquinoline,the ultimate get the product 8-(4-phenyl-1H-1,2,3-triazol-1-yl)quinoline by click reaction,In this study,the low cost catalysts,phase transfer catalyst,water and Cu(I) were used,get the product with "one pot reaction" at room temperature,and yield up to 90%. |
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| Keywords: | 8-(4-phenyl-1H-1 2 3-triazol-1-yl)quinoline click chemistry synthesis |
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