Construction of pH-responsive drug delivery platform with calcium carbonate microspheres induced by chitosan gels |
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Authors: | Jingwei Wang Yong Kong Feng Liu Dan Shou Yongxin Tao Yong Qin |
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Affiliation: | 1. Advanced Catalysis and Green Manufacturing Collaborative Innovation Center, Changzhou University, Changzhou 213164, China;2. Department of Medicine, Zhejiang Academy of Traditional Chinese Medicine, Hangzhou 310007, China |
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Abstract: | Construction of simple and convenient platforms for controlled delivery of anti-cancer drugs is of great importance for medical science and pharmaceutics. Here, chitosan (CS) gels were used to induce the growth of calcium carbonate (CaCO3) microspheres, and the resulting CaCO3 microspheres were well dispersed within the three-dimensional (3D) network framework of the CS gels. The synthesized CaCO3/CS composites were then examined by field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), Fourier transform infrared spectrometry (FT-IR) and X-ray diffractometry (XRD). Finally, the designed CaCO3/CS composites were used for loading and controlled delivery of methotrexate (MTX), an anti-cancer drug. The encapsulation ratio of MTX calculated by UV–vis spectroscopy was approximately 78.8%. In addition, pH-responsive delivery of MTX from the CaCO3/CS composites was successfully achieved due to the pH-sensitive property of CS, and the cumulative release of MTX could reach 93.3%, 86.6% and 77.6% at pH 8.5, 7.4 and 5.8, respectively. |
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Keywords: | pH-Responsive Drug carrier Chitosan gels Methotrexate |
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