| 复方替米考星纳米乳的制备及其质量评价 |
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| 引用本文： | 胡帅,欧阳五庆,杨雪峰. 复方替米考星纳米乳的制备及其质量评价[J]. 精细化工, 2009, 26(8) |
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| 作者姓名： | 胡帅 欧阳五庆 杨雪峰 |
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| 作者单位： | 西北农林科技大学,动物医学院,陕西,杨凌,712100;西北农林科技大学,动物医学院,陕西,杨凌,712100;河南科技学院,动物科学学院,河南,新乡,453003 |
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| 基金项目： | 国家科技支撑计划(2006BAD04A11)~~ |
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| 摘 要： | 研制了复方替米考星纳米乳(TMS-TMPL-NE)并对其进行了质量评价。通过绘制伪三元相图优选处方,以肉豆蔻异丙酯(IPM)为油相,吐温80为表面活性剂,m(无水乙醇)/m(1,2-丙二醇,PG)=3为助表面活性剂,磷酸为增溶剂,制备了TMS-TMPL-NE,用透射电子显微镜(TEM)、Nicomp388/ZetaPALS激光粒度测定仪分别考察了其形态和粒径,通过恒温加速实验检验了其稳定性。纳米乳在透射电镜下呈圆球形,分布均匀,粒径为12.4nm,多分散系数(PDI)为0.051,恒温加速实验结果显示其未分层,仍为澄清透明纳米乳状液。TMS-TMPL-NE稳定性好,制备工艺简单,有望应用于兽医临床。
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| 关 键 词： | 替米考星 乳酸甲氧苄啶 纳米乳 伪三元相图 质量评价 医药与日化原料 |
Preparation and Quality Evaluation of Compound Timicosion Nanoemulsion |
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| HU Shuai,OUYANG Wu-qing,YANG Xue-feng. Preparation and Quality Evaluation of Compound Timicosion Nanoemulsion[J]. Fine Chemicals, 2009, 26(8) |
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| Authors: | HU Shuai OUYANG Wu-qing YANG Xue-feng |
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| Affiliation: | 1.College of Veterinary Medicine;Northwest A & F University;Yangling 712100;Shaanxi;China;2.College of Animal Science;Henan Institute of Science and Technology;Xinxiang 453003;Henan;China |
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| Abstract: | The aim of this paper is to study the preparation and quality evaluation of compound timicosion and trimethoprim lactate nanoemulsion(TMS-TMPL-NE).The formulations of TMS-TMPL-NE were optimized by protracting the pseudoternary phase diagrams,taking IPM,tween80,m(ethanol)/m(propylene glycol,PG)=3,phosphoric acid,timicosion and trimethoprim lactate to prepare TMS-TMPL-NE.TEM and Particle Sizing System reviewed its shape and particle size distribution and constant temperature accelerated experimentation to ver... |
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| Keywords: | timicosion trimethoprim lactate nanoemulsion pseudoternary phase diagram quality evaluation drug and cosmetic materials |
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