| 4-哌啶醇的精制工艺研究 |
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| 引用本文： | 张惠,陈效毅,安顺永.4-哌啶醇的精制工艺研究[J].精细与专用化学品,2009,17(1):26-27. |
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| 作者姓名： | 张惠 陈效毅 安顺永 |
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| 作者单位： | 1. 徐州工业职业技术学院环境工程系,江苏 徐州,221140
2. 徐州化工研究所,江苏 徐州,221000 |
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| 摘 要： | 4-哌啶醇是医药产品的重要中间体．新开发的药物如抗精神病药物氟哌啶醇、癸酸氟哌啶醇等都含有哌啶醇结构。因为4-哌啶醇具有止痛作用，还可用来合成口服止痛专利药和治疗神经性疼痛的专利药物．如止痛药哌吡唑酮、芬太尼（Fentanyl）和神经性疼痛治疗药氟哌啶醇（Haloperidol）等。
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| 关 键 词： | 哌啶醇 精制工艺 止痛药 医药产品 药物 精神病 中间体 吡唑酮 |
Research on Purification Process of 4-Hydroxypiperidine |
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| ZHANG Hui.Research on Purification Process of 4-Hydroxypiperidine[J].Fine and Specialty Chemicals,2009,17(1):26-27. |
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| Authors: | ZHANG Hui |
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| Affiliation: | Department of Environmental Engineering;Xuzhou College of Industrial Technology;Xuzhou 221140;China |
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| Abstract: | In the synthesis of 4-hydroxypiperidine only the product with most of its salt can be obtained owing to its strong protophilic property,so the free title compound can't be separated and purified from its salt with ordinary recrystallization process at all.The present article provides a facile and efficient method to obtain free title compound based on cheap, less pollutant compounds as raw materials with simple purification process to refine 4- hydroxypiperidine from its salt.The process is suitable to its ... |
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| Keywords: | 4-hydroxypiperidine purification free compound industrialized production |
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