Fish Oil Supplementation During Late Pregnancy Does Not Influence Plasma Lipids or Lipoprotein Levels in Young Adult Offspring |
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Authors: | Dorte Rytter Erik B Schmidt Bodil H Bech Jeppe H Christensen Tine B Henriksen Sjurdur F Olsen |
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Affiliation: | 1.Department of Epidemiology,School of Public Health, Aarhus University,Aarhus,Denmark;2.Department of Cardiology and Center for Cardiovascular Disease,Aalborg Hospital, Aarhus University Hospital,Aalborg,Denmark;3.Department of Nephrology and Center for Cardiovascular Disease,Aalborg Hospital, Aarhus University Hospital,Aalborg,Denmark;4.Department of Pediatrics,Aarhus University Hospital,Skejby,Denmark;5.Centre for Fetal Programming,Statens Serum Institut,Amager,Denmark |
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Abstract: | Nutritional influences on cardiovascular disease operate throughout life. Studies in both experimental animals and humans
have suggested that changes in the peri- and early post-natal nutrition can affect the development of the various components
of the metabolic syndrome in adult life. This has lead to the hypothesis that n-3 fatty acid supplementation in pregnancy
may have a beneficial effect on lipid profile in the offspring. The aim of the present study was to investigate the effect
of supplementation with n-3 fatty acids during the third trimester of pregnancy on lipids and lipoproteins in the 19-year-old
offspring. The study was based on the follow-up of a randomized controlled trial from 1990 where 533 pregnant women were randomized
to fish oil (n = 266), olive oil (n = 136) or no oil (n = 131). In 2009, the offspring were invited to a physical examination including blood sampling. A total of 243 of the offspring
participated. Lipid values did not differ between the fish oil and olive oil groups. The relative adjusted difference (95%
confidence intervals) in lipid concentrations was −3% (−11; 7) for LDL cholesterol, 3% (−3; 10) for HDL cholesterol, −1% (−6;
5) for total cholesterol,−4% (−16; 10) for TAG concentrations, 2%(−2; 7) for apolipoprotein A1, −1% (−9; 7) for apolipoprotein
B and 3% (−7; 15) in relative abundance of small dense LDL. In conclusion, there was no effect of fish oil supplementation
during the third trimester of pregnancy on offspring plasma lipids and lipoproteins in adolescence. |
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