Senile dementia-Alzheimer's type and estrogen |
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Authors: | H Honjo K Tanaka T Kashiwagi M Urabe H Okada M Hayashi K Hayashi |
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Affiliation: | Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine, Japan. |
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Abstract: | Some reports have suggested the ameliorative effects of estrogens on clinical symptoms, such as short memory, in women suffering from senile dementia-Alzheimer's type, in vivo. The action mechanism of estrogen remains to be clarified, but 1) an anti-depressive effect, 2) improvement of cerebral blood flow, 3) direct stimulation of neuron, 4) development of gliacyte and 5) suppression of apolipoprotein E have been suggested. Some mechanisms may be combined, contributing to the beneficial effects on clinical symptoms. |
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