| 5-甲基胞嘧啶的合成 |
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| 引用本文： | 单绍军,李心恬,黄善东,方红,陈麒宇. 5-甲基胞嘧啶的合成[J]. 辽宁化工, 2010, 39(6): 582-582,608 |
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| 作者姓名： | 单绍军 李心恬 黄善东 方红 陈麒宇 |
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| 作者单位： | 1. 广东药学院医药化工学院,广东,中山528485
2. 深圳出入境检验检疫局工业品检测技术中心,广东,深圳,518045 |
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| 摘 要： | 5-甲基胞嘧啶是一个非常重要的医药中间体,用来制备抗病毒和抗肿瘤等药物。以5-甲基脲嘧啶为原料,先与三氮唑反应制得中间体5-甲基-4-(1,2,4-三氮唑)-嘧啶-2-酮,接着该中间体在浓氨水的作用下水解生成最终产物5-甲基胞嘧啶,总收率为24.4%。
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| 关 键 词： | 5-甲基胞嘧啶 5-甲基脲嘧啶 合成 |
Synthesis of 5-methylcytosine |
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| SHAN Shao-jun,LI Xin-tian,HUANG Shan-dong,FANG Hong,CHEN Qi-yu. Synthesis of 5-methylcytosine[J]. Liaoning Chemical Industry, 2010, 39(6): 582-582,608 |
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| Authors: | SHAN Shao-jun LI Xin-tian HUANG Shan-dong FANG Hong CHEN Qi-yu |
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| Affiliation: | 1.School of Chemistry and Chemical Engineering,Guangdong Pharmaceutical University,Zhongshan 528485,China;2.Shenzhen Entry-exit Inspection and Quarantine Bureau,Shenzhen 518045,China) |
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| Abstract: | 5-Methylcytosine is an important pharmaceutical intermediate for production of antiviral and anticancer drugs etc..5-methylcytosine was synthesized from concentrated aqueous ammonia and 5-methyl-4-（1,2,4-triazol-1-yl）-pyrymidin-2-（1H）-2-one which was prepared from triazole and thymine.overall yield was 24.4%. |
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| Keywords: | 5-Methylcytosine Thymine Synthesis |
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