| 气相色谱法测定阿莫西林克拉维酸钾片中的乙醇残留量 |
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| 引用本文： | 孔霁虹,臧恒昌,王彦厚. 气相色谱法测定阿莫西林克拉维酸钾片中的乙醇残留量[J]. 食品与药品, 2014, 0(2): 120-122 |
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| 作者姓名： | 孔霁虹 臧恒昌 王彦厚 |
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| 作者单位： | [1]山东大学药学院,山东济南250012 [2]瑞阳制药有限公司,山东淄博256100 [3]淄博市食品药品检验所,山东淄博255086 |
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| 摘 要： | 目的建立一种测定阿莫西林克拉维酸钾片中乙醇残留量的方法。方法采用气相色谱法测定乙醇残留量,载气为氮气。结果 0.316~2.37μg/mL范围内,峰面积与乙醇浓度间呈良好的线性关系。结论该方法操作简单、准确、重复性好、灵敏度高,可用于阿莫西林克拉维酸钾片中乙醇残留量的测定。
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| 关 键 词： | 阿莫西林克拉维酸钾片 乙醇 残留溶剂 气相色谱法 |
Determination of Ethanol in Amoxicillin and Clavulanate Potassium Tablets by Gas Chromatography |
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| KONG Ji-hong,ZANG Heng-chang,WANG Yan-hou. Determination of Ethanol in Amoxicillin and Clavulanate Potassium Tablets by Gas Chromatography[J]. Food and Drug, 2014, 0(2): 120-122 |
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| Authors: | KONG Ji-hong ZANG Heng-chang WANG Yan-hou |
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| Affiliation: | 1. School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China; 2. Reyoung Pharmaceutical Co., Ltd., Zibo 256100, China; 3. Zibo Institute for Food and Drug Control, Zibo 255086, China) |
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| Abstract: | Objective To establish a method for the determination of residual ethanol in Amoxicillin and Clavulanate Potassium Tablets. Methods GC with FID detector was adopted, and nitrogen was selected as the carrier gas. Results There is an excellent linearity between the peak area and the content of ethanol in the range of 0.316-2.37 g/mL. Conclusion The method was simple, accurate and of good reproducibility, and can be used for the determination of residual ethanol in Amoxicillin and Clavulanate Potassium Tablets. |
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| Keywords: | Amoxicillin and Clavulanate Potassium Tablets ethanol residual solvent GC |
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