Electrogenerated base-promoted synthesis and antimicrobial activity of 2-imino-1,3-thiazolidin-4-one derivatives |
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| Authors: | Beya Haouas Taieb Saied Hanen Ayari Youssef Arfaoui Mohamed Lamine Benkhoud Khaled Boujlel |
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| Affiliation: | 1. Laboratory of Analytic Chemistry and Electrochemistry, Department of Chemistry, Faculty of Science, University of Tunis, El Manar, Tunisia;2. Department of Chemistry and Applied Biology, National Institute of Applied Sciences and Technology, Tunis Cedex, Tunisia;3. Laboratory of Physical Chemistry of Condensed Materials, Department of Chemistry, Faculty of Science, University of Tunis, El Manar, Tunisia |
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| Abstract: | Electrogenerated cyanomethylanions obtained by reduction of dry acetonitrile at a steel grid cathode were used to promote the addition of ethyl bromoacetate to thiourea derivatives. The reaction yields the corresponding 2-imino-1,3-thiazolidin-4-one. The reaction pathway was discussed based on the kinetic and thermodynamic data obtained by computational methods. In addition, the biological activity of these new compounds was also investigated. |
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| Keywords: | Thiourea thiazolidinone acetonitrile electrogenerated base antimicrobial activity |
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